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Engineered ketoreductase polypeptides, compositions comprising them, methods of reducing substrates and methods for synthesizing intermediates
Engineered ketoreductase polypeptides, compositions comprising them, methods of reducing substrates and methods for synthesizing intermediates
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机译:工程化的酮还原酶多肽,包含它们的组合物,还原底物的方法和合成中间体的方法
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摘要
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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