A PROCESS FOR PREPARING CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS OF MINOCYCLINE

摘要

The present invention relates to a process for preparing controlled release pharmaceutical compositions of 7-dimethylamino-6-deoxy- 6-demethyltetracycline (minocycline) or non-toxic acid addition salts thereof. More particularly, it relates to a once-a-day delivery system for minocycline, which maintains its therapeutic plasma concentrations in a patient for twenty-four hours.