RAPIDLY DISINTEGRATING LYOPHILIZED ORAL FORMULATIONS OF A THROMBIN RECEPTOR ANTAGONIST

摘要

I)i,si.'liiMC(l is II lyophili/cci rapidly tlisinlcgraliiig suliti ditHii).',!' Intiii. one embodimeiil of which comprises a thrombin receptor imlanoiiiNl Hueh ns, lormiihi (A), or a pharmaceuticnlly acceplable salt or hy(h'alc Ihcreol, a p«)lymer such as gelatin, and a matrix forming agent such as mannllol. NvHlemn lor cITeclively buffering Ihc prc-lyophlli/ed suspension are taughl. along wllh nu'lhodn t)riri'aling patients al lisk for acute coronary syndrome by adnilnlnlering siicli a rapidly disintegraling solid dosage form.