INDUCTION OF AN IMMUNE RESPONSE AGAINST DENGUE VIRUS USING PRIME-BOOST APPROACH

摘要

Abstract INDUCTION OF AN IMMUNE RESPONSE AGAINST DENGUE VIRUS USING PRIME-BOOST APPROACH The invention relates to methods for the induction of an immune response to denge virus. The method of inducing an immune response against dengue virus comprising administration of a non-repplicating immunogen followed by a boost with a tetravalent Jive attenuated viral vaccine. Another aspect of the inventive subject matter is a method of inducing an immune response against dengue virus using a heterologous prime-boost regiment with the priming immunogen comprising a DNA expression system, an adenovirus expression vector or a Venezuelan equine encephalitis virus replicon system and the boosting immunogen comprising the same without the DNA expression system. Each expression system contains DNA sequences encoding dengue viral proteins.