PROCESS FOR THE PREPARATION OF A SOLID DOSAGE FORM, IN PARTICULAR A TABLET, FOR PHARMACEUTICAL USE AND PROCESS FOR THE PREPARATION OF A PRECURSOR FOR A SOLID DOSAGE FORM, IN PARTICULAR A TABLET

摘要

The present invention refers to a process for preparing a powder comprising the steps of providing at least one first component being in liquid form at ambient temperature, in particular having a viscous liquid consistency, such as for example an oil; or having a waxy consistency at ambient temperature, in particular a component which is a solid or semi-solid at ambient temperature and which has an onset of melting in the temperature range from 15 0 C to 40 0 C, providing at least one second component having a melting point or melting range in the range from above ambient temperature to below the degradation temperature of said first component, in particular in the range from above ambient temperature to 120 0 C, more in particular in the range from 40 °C to 120°C, even more in particular in the range from 50°C to 120°C, even further in particular in the range from 55°C to 120°C, forming a homogenous liquid mixture comprising said at least one first component and said at least one second component by stirring and heating the mixture to or keeping the mixture at a temperature in the range from above the melting point or melting range of said second component and below the degradation temperature of said first component, in particular in the range from above the melting point or melting range of said second component to 120 0 C, transferring the liquid mixture to at least one spray congealing unit by at least one transfer unit, which is adapted to keep the mixture in its liquid form during its transfer, spray congealing said mixture, and isolating the powder obtained upon spray congealing. Further, the present invention refers to a process for the preparation of a solid dosage form comprising the powder resulting from the above process.