SYSTEM FOR DELIVERING ASCORBIC ACID IN LIPOSOME CONTAINING PHOSPHOLIPID

摘要

A topical delivery system comprising liposome encapsulating ascorbic acid wherein the liposome is formed from surfactants (e.g. phospholipids, cationic surfactants, anionic surfactants), sterols such as cholesterol, fatty acids and/ or hydrophobically modified surfaceactive polymers. The stable liposomal composition of ascorbic acid comprising, 0.01% to about 20% by weight aqueous solution of ascorbic acid wherein said ascorbic acid is pure and stable up to pH 7.0. A process for preparing the liposomal composition of ascorbic acid comprising (a) dissolving sterol, surface-active polymers, fatty acids in ethanol, (b) ascorbic acid solution in cooled boiled water, (c) adding the ascorbic acid solution obtained from step (b) to the mixture obtained from step (a) drop by drop under constant stirring condition, (d) mixing solution comprising surfactant and surface-active polymer and adding to the above mixture obtained from . step (c) under constant stirring and (e) adjusting pH of the solution to 6 to 7 using alkali.