STANDARDIZATION AND EVALUATION OF ANTI TUMOUR ACTIVITY OF SIDDHA FORMULATION GURU PATHANGAM AGAINST DALTON ASCITES LYMPHOMA IN MICE

摘要

In the present study the Guru pathangam was studied for its antitumour effect against transplantable tumour. A significant improvement of MST and peritoneal cell count were observed in the tumour-induced animals. From these results, it can be concluded that the Guru pathangam at 5mg/kg dose level posses anti tumour effect against DAL cells probably by activation of macrophages or by some cytokine product release inside the peritoneal cavity. The total WBC count and PCV were found to increase with a reduction in the hemoglobin content of RBC. At the same time interval, Guru Pathangam (5mg/kg per day p.o.) treatment changed this altered parameters to near normal. The antitumor effect of the Guru pathangam is evident from the increase in lifespan, reduction in solid tumour volume and also the reversal of altered haematological parameter almost equal to normal. All these data confirms that the Guru pathangam usage as a potential agent in the area of cancer chemotherapy.