'DRUG DELIVERY SYSTEMS (WAFER) FOR PEDIATRIC USE'

摘要

The present invention describes drug delivery compositions in the form of thin water-soluble films (wafers), which contain particles that comprise at least one active ingredient -which is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl- (6S)-tetrahydrofolate- and at least one protective agent. The protective agent provides effective taste-masking of the active ingredient due to limited release of the active ingredient in the mouth. The active ingredient is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route. The particles contained in the wafer provided by the present invention have a particle size of below 40 urn thereby resulting in an acceptable sensation in the mouth while dissolving. Such wafers are especially suitable for pediatric use.