CHALCHONE DERIVATIVES FOR POST MENOPAUSAL AND ANDROGEN DEFICIENCY RELATED TEAR DEFICIENCY AND OCULAR INFLAMMATION

摘要

The present invention relates to structurally modified chalcone derivatives exhibiting improved solubility and having affinity for all the sex steroid receptors i.e. Estrogen -Alpha, Estrogen - Beta and androgen receptors. The chalcone derivative(s) are flavones(s)/Isoflavone(s)/ chalcone(s). The Invention also provides a topical eye formulation comprising said structurally modified flavones(s)/Isoflavone(s) and chalcone(s). The structurally modified derivative(s) also have applications in foodstuffs, beverages, dietary supplements, and pharmaceutical compositions.