NOVEL ORGANOCATALYTIC ASYMMETRIC SYNTHESES OF ANTIDEPRESSANTS-(+)- SERTRALINE AND TAMETRALINE

摘要

ABSTRACT AN ORGANOCATALYTIC ASYMMETRIC SYNTHESIS OF ANTIDEPRESSANTS The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. wherein R1 and R2 represent independent of each other hydrogen, (un)substituted or substituted amine; R3 and R4 represent independent of each other hydrogen or halogen.