PH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT COMPOSITIONS THEREFROM AND MAKING AND USING SAME

摘要

Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI) ophthalmic urinary or reproductive tracts. Unexpectedly carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus stomach and duodenum) (b) acid labile (c) impermeable/insoluble compounds in GI fluids (d) susceptible to first pass metabolism and/or (e) cause stomach irritation upset or dyspepsia.