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NOVEL DERIVATIZATION METHOD FOR DETERMINATION OF ASPIRIN AND CARISOPRODOL IN PHARMACEUTICAL FORMULATIONS.
NOVEL DERIVATIZATION METHOD FOR DETERMINATION OF ASPIRIN AND CARISOPRODOL IN PHARMACEUTICAL FORMULATIONS.
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机译:新型衍生化方法测定药物配方中的阿司匹林和卡硝酚。
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摘要
A simple, accurate, precise and novel derivative UV Spectrophotometric method was developed and validated for simultaneous estimation of Aspirin and Carisoprodol in its combined tablet dosage form. As the drug Carisoprodol does not contain chromophoric group it becomes difficult to quantify it with UV spectrophotometer. Hence, the derivatization was carried out in order to make the drug Carisoprodol to give absorbance in UV region. The T'LC, FTIR and Mass spectra of both derivative products were taken to confirm the final derivative products. The method adopted for the derivatization was simple and economic as compared to methods available previously, with stable derivatives. Absorbance Correction method was applied for simultaneous estimation of Aspirin and Carisoprodol and determination was carried out at 251.5 nm and 314 nm. The linearity range was observed between 12-36ug/ml for Aspirin and 8-24ug/ml for Carisoprodol for developed method. Both the drugs were found in good agreement with the labelled claim in the marketed formulation. In tablet dosage form, Aspirin and Carisoprodol were estimated to 98.44 �0.55 & 98.50�0.97% respectively. Developed method was statistically validated for its linearity, accuracy, precision and robustness.
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