INHIBITORS OF ALPHA CRYSTALLIN AGGREGATION FOR THE TREATMENT FOR CATARACT

摘要

The invention provides inhibitors of cc crystallin aggregation and methods of using cc crystallin aggregation inhibitors to e.g. treat or prevent cataracts in a subject having or at risk of developing cataracts. The invention further provides high throughput methods of screening compounds for modulation of protein thermal stability the method comprising contacting a protein with each of a plurality of test compounds; and (b) measuring the melting transition (Tm) of the protein in the presence of each of the plurality of test compounds wherein a compound that decreases or increases the apparent Tm by at least 2 standard deviations is identified as a pharmacological protein chaperone.