PROCESS OF SYNTHESIS OF BIOLOGICALLY IMPORTANT SEMICARBAZONES COPPER

摘要

A novel divalent macrocyclic copper (II) complexes are disclosed. The divalent copper species are directly produced by the template method with a combination of substituted carbohydrazone; tridentated semicarbazide hydrochloride and copper (II) chloride. The divalent copper (II) complexes were characterized by elemental analysis, IR, iTNMR, mass and electronic spectra.. The magnetic moments and electronic spectral studies suggested distorted octahedral geometry for all the complexes. The Cytotoxic activity against human Breast Cancer Cell line MCF-7, antibacterial- and antioxidant activities were evaluated for all synthesized compounds. The standard anti-breast cancer drug Tamoxifen was used as a positive control. The synthesized compounds were screened for their in vitro antibacterial activity using Disc Diffusion method against two strains each of gram negative and gram positive bacteria. Tetracycline was used as positive control. In-vitro antioxidant activity of all macrocyclic copper complexes was screened using the DPPH scavenging assay. All compounds showed potent antioxidant activity in the range 60-80%.