Methods of producing 6 carbon chemicals via coa dependent carbon chain elongation associated with carbon storage

摘要

This document describes biochemical pathways for producing adipic acid caprolactam 6 aminohexanoic acid 6 hydroxyhexanoic acid hexamethylenediamine or 1 6 hexanediol by forming two terminal functional groups comprised of carboxyl amine or hydroxyl groups in a C6 aliphatic backbone substrate. These pathways metabolic engineering and cultivation strategies described herein rely on CoA dependent elongation enzymes or analogues enzymes associated with the carbon storage pathways from polyhydroxyalkanoate accumulating bacteria.