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METHODS AND COMPOSITIONS FOR TREATING CANCERS HAVING ACQUIRED RESISTANCE TO CHEMOTHERAPEUTIC AND TARGETED DRUGS USING CARBOXYAMIDOTRIAZOLE OROTATE
METHODS AND COMPOSITIONS FOR TREATING CANCERS HAVING ACQUIRED RESISTANCE TO CHEMOTHERAPEUTIC AND TARGETED DRUGS USING CARBOXYAMIDOTRIAZOLE OROTATE
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机译:使用羧酰胺基三唑乳清酸盐治疗对化疗药物和靶向药物具有耐药性的治疗方法和组合物
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摘要
This invention provides methods and compositions useful for treating early and late stage metastatic cancer to prevent or treat acquired resistance due to gene amplification or mutation in response to chemotherapeutic and/or targeted drugs. In particular the methods and compositions include carboxiamidotriazole orotate (CTO) alone or in combination with specific regimens of chemotherapeutic and/or targeted drugs designed to overcome the genomic resistance raised to prior therapy.
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