DIAGNOSTIC AND PROGNOSTIC BIOMARKERS FOR PROSTATE CANCER AND OTHER DISORDERS

摘要

The present invention relates to the use of VPS28 and/or VPS13A as biomarkers for diagnosing prostate cancer, prostate intraepithelial neoplasia (PIN) or atypical small acinar proliferation (ASAP) and to the use of VPS 13A, VPS28 and/or NAALADL2 as biomarkers for predicting the prognosis of prostate cancer. The invention also relates to the use of VPS 13A, VPS28 and/or NAALADL2 as biomarkers for determining the grade or pathological stage of prostate cancer and monitoring progression of prostate cancer. In addition, the invention relates to the use of NAALADL2 as a biomarker for diagnosing colon, pancreatic or breast cancer. Assays, systems and storage media based on the use of these biomarkers are also provided.