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AN ISOLATED RECOMBINANT VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN (HRVCP) POLYPEPTIDE
AN ISOLATED RECOMBINANT VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN (HRVCP) POLYPEPTIDE
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机译:分离的重组痘苗病毒补体控制蛋白(HRVCP)多肽
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摘要
An isolated recombinant vaccinia virus complement control protein (hrVCP) polypeptide comprises a modified amino acid sequence comprising one or more amino acid substitutions to an amino acid sequence as set forth in SEQ ID NO: 2. The hrVCP polypeptide exhibits a complement activation regulatory activity greater than a complement activation regulatory activity of a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO: 2. The one or more amino acid substitutions are selected from the group consisting of H98Y, E102K, E108K, E120K, and combinations thereof.
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机译:分离的重组痘苗病毒补体控制蛋白(hrVCP)多肽包含修饰的氨基酸序列,该氨基酸序列包含一个或多个如SEQ ID NO:2所示氨基酸序列的氨基酸取代。hrVCP多肽表现出更大的补体激活调节活性。氨基酸序列包括包含SEQ ID NO:2所示氨基酸序列的多肽的补体激活调节活性。一个或多个氨基酸取代选自H98Y,E102K,E108K,E120K及其组合。
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