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DIMETHYL FUMARATE AND ITS PHARMACEUTICALLY ACCEPTABLE DERIVATIVES (TECFIDERA)
DIMETHYL FUMARATE AND ITS PHARMACEUTICALLY ACCEPTABLE DERIVATIVES (TECFIDERA)
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机译:富马酸二甲酯及其药学可接受的衍生物(TECFIDERA)
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摘要
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designed to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.
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