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INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS.
INTERLEUKIN-2 MUTEINS FOR THE EXPANSION OF T-REGULATORY CELLS.
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机译:白介素2突变蛋白可扩展T调节细胞。
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摘要
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.
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