METHOD FOR ENZYMATIC SYNTHESIS OF (7S)-3,4-DIMETHOXYBICYCLO4.2.0 OCTA-1,3,5-TRIENE-7-CARBOXYLIC ACID OR THE ESTERS THEREOF, AND USE FOR THE SYNTHESIS OF IVABRADINE AND THE SALTS THEREO.

摘要

Process for the enzymatic synthesis of the compound of formula (I): wherein R1 represents a hydrogen atom or an alkyl group. Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.