Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition

摘要

Discloses the use of an anti-Adrenomedullin (ADM) antibody or an anti-ADM antibody fragment binding to adrenomedullin or anti-ADM non-Ig scaffold binding to adrenomedullin in the manufacture of a medicament for use in therapy of an acute disease or acute condition of a patient for prevention or reduction of organ dysfunction or prevention of organ failure in said patient, wherein said antibody or antibody fragment or non-Ig scaffold binds to a region of at least 4 amino acids within the sequence of aa1-42 of mature human ADM (SEQ ID NO: 24), and wherein said organ is selected from the group comprising heart, kidney, liver, lungs, pancreas, small intestines and spleen, wherein the sequences are as defined in the complete specification.