Macrocycle inhibitors of proteinA / proteinA de proteinA de providina programenta 1 (PD-1) / programendo de death 1 (PD-L1) and difference 80 (B7-1) CD80 (B7-1) / scheduled death alliance 1 (PD-L1)

摘要

It refers to the macroscopical epoxy foam with the same pharmaceutically acceptable formula (I) or salt. Its characteristics are as follows: a es-ch [C (o) NH2] - (CH2) n-ch2-s-ch2 - * * *,-CH C (O) NH2 - (CH2) n-CH2-S (O) -CH2--CH C (O) NH2 - (CH2) n-CH2-S (O) 2-CH2--CH C (O) NH2 - (CH2) n-CH2- O -CH C (O) NH2 - (CH2) n-CH 3DCH-AMONG OTHERS, WHERE * INDICATES THE POINT OF UNION TO CARBONYL; n IS 0 or 1; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 AND R13 ARE INDEPENDENTLY A SIDE CHAIN OF NON-NATURAL AMINO ACID, AMONG OTHERS; Ra, Re, Rj and Rk ARE INDEPENDENTLY H OR METHYL; Rc, Rf, Rh, Ri, Rm, and Rn ARE H; Rb IS METHYL; Rd IS H O METHYL; Rg IS H O METHYL; OR Rb AND R2, Rd AND R4, OR Rg AND R7, AMONG OTHERS, TOGETHER WITH THE ATOMS TO WHICH THEY ARE UNITED ARE AZETIDINE, PIRROLIDINE, MORPHOLINE, PIPERIDINE OR PIPERAZINE, AMONG OTHERS. THE MACROCYCLIC PEPTIDES OF FORMULA (I) INHIBIT THE PROTEIN / PROTEIN INTERACTION PPD-1 / PD-L1 AND PD-L1 / CD80, SO THEY ARE USEFUL IN THE THERAPY OF SEVERAL DISEASES,Including cancer and infectious diseases