3-acetamide-1 (phenyl heteromorphic carbides or phenyl heteromorphic carbonates) derivatives for the treatment of highly diffused dispersion

摘要

It refers to an alternative derivative of N - (phenyl - iso-1-ol) - 3-acetamide-benzene zamida or N - [3 - (acetamide) phenyl] - phenyl - iso-1-ol-amino (I) of general formula.A. It is methylene or ethylene, among others; LB es-nhc (o) - O-C (o) NH -;R2 is Pyridine-2, 5-ileno, furil-2, 5-ileno, tien-2, 5-ileno, tiazol-2, 5-ileno, etc.; R3 is optional, replacing one or more halogens with one or more halogens, O H, NH2, CN, NO2, etc.; R4 is h or c1-c3-tar; R5 is h, C1, C1, c1-c3-c3-c3-c3; R6 is c1-c6-tar, c1-c6-alcoxi, halo, oh, CN, arilo, thermal, enter otros These compounds inhibit one or more Wnt senalizacion cascade members and are therefore useful in the treatment of cancer and other diseases related to abnormal vascular diseases,Cell diffusion and cell circulation It also refers to the preparation method of these compounds, the preparation of intermediate compounds, the pharmacological synthesis and the combination containing these compounds.