1,2,4-triazole derivative: 5-(2,3-dichlorophenyl)-4-pentyl-2,4-dihydro-3H-1,2,4-triazole-3-thione, a method for its preparation and its first medical application

摘要

the subject invention is a derivative of 1,2,4 - triazole of general formula 1, and its farmaceutycznie acceptable salts.the subject is also a way to produce derivatives of 5 - (2,3-dichlorophenyl) - 4 - pentyl - 2,4 - dihydro 3h 1,2,4 triazolo - 3 - tionu of general formula 1 and their farmaceutycznie acceptable salt, which is that maleic 2,3 methylester to undergo reaction with izotiocyjaniane m pentyl, whereby the reaction is in a mole ratio of 1: 1.on foot or in polar solvents.in the case of a reaction mixture in a substrate heated at 100 - 140u00b0c by 1 - 10 minutesand, in the case of reaction in polar solvent and environment especially ethyl alcohol process leads in boiling point solvent for a period of 5 - 30 minutes pre after cooling and resulting product odsu0105cza crystallizes with a suitable solvent polarpreferably with ethanol and obtained a tiosemikarbazydu undergo reaction cyklizacji in aqueous hydroxide solution, after which the solution is an aqueous solution of hydrochloric acid to obtain a reaction, preferably an acidic, and the precipitated compound model 1, crystallizes with answering edniego polar solvent, preferably ethanol.the invention also includes 1,2,4 triazole derivative of general formula 1, and its farmaceutycznie acceptable salts for use as medicine.