Functionalized coating in medical device, method for producing functionalized coating and the medical device covered with such a coating

摘要

disclosed funkcjonalizowanu0105 coating located on at least part of the medical device, characterised by the fact that contains: an embedding surface coating equipment based on titanium ti (iv), usieciowanu0105 in an acidic environment, the method zol - gel precursor to shave new formula ti (or) 4, where r is a straight chain or branched alkyl.the coating includes optionally surfactant; modifying the surface structure of the coating functional group - nh2 or - sh, connected by sylanizacji with amino - or thio - a view krzemoorganicznego containing hydrocarbon chains c1 - c4, with the creation of funkcjonalizowanej coating ti (iv) - nh2 or - sh, ti (iv)connected on the surface of the coating and ti (iv) - nh2 or ti (iv) - sh at least one type of antibody or antibody fragment specific for types of membrane antigens of endothelial cells (ec) or endothelial precursor cells (epc), with associated to the antibodies or fragments of antibodies are alternatively glycosylated form, which is not oxidized.the subject solutions is also the way to produce coatings and the coated medical device coating.