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process for the production of compounds of 177lu highly pure without support and composed of 177lu without support.
process for the production of compounds of 177lu highly pure without support and composed of 177lu without support.
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机译:无载体的高纯度177lu化合物的生产方法,该化合物由无载体的177lu组成。
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摘要
Producing carrier-free and ultra-pure lutetium-177 compounds for medical and/or diagnostic purposes from ytterbium-176 compounds irradiated with thermal neutrons, comprises: (a) loading a first column (VS1), which is packed with a cation exchange material containing starting materials dissolved in mineral acid, (b) connecting output of first column with input of a second column (S1), (c) applying gradient of water and a complexing agent, (d) detecting the radioactivity dose to detect an elution of lutetium-177 compounds, (e) loading final separating column, and (f) eluting lutetium-177 ions. Producing carrier-free and ultra-pure lutetium-177 compounds for medical and/or diagnostic purposes from ytterbium-176 compounds irradiated with thermal neutrons, comprises: (a) loading a first column (VS1), which is packed with a cation exchange material containing the starting materials dissolved in the mineral acid, replacing the protons of the cation exchange material for ammonium ions using a solution of ammonium chloride, and rinsing the cation exchange material of the first column with water, where the end products of the neutron irradiation comprise a mixture of the lutetium-177 and ytterbium-176 in a mass ratio of 1:10 2-1: 10 1 0, are used as the starting materials, and the starting materials, which are insoluble in water, are converted into a soluble form by mineral acids, (b) connecting the output of the first column with the input of a second column, which is also packed with cation exchange material, (c) applying a gradient of water and a complexing agent including alpha -hydroxyisobutyrate (HIBA), citric acid, citrate, butyric acid, butyrate, EDTA, ethylene glycol tetraacetic acid (EGTA), and ammonium ions, starting from 100% of water-0.2 M complexing agent to the input of the first column to elute lutetium-177 compounds of the first and the second column, (d) detecting the radioactivity dose at the output of the second column, to detect an elution of lutetium-177 compounds, collecting a first eluate of lutetium-177 compounds from output of the second column in a container (F3), and protonating the complexing agent to make them ineffective for the complex formation with lutetium-177 ions, (e) loading a final separating column, which is packed with cation exchange material, by continuous propagation of the acidic lutetium-177 eluate obtained from the step (d) to the input of the final separating column, washing the complexing agent with dilute mineral acid at a concentration of less than 0.1 M, removing foreign metal ion traces from the lutetium-177 solution by washing the cation exchange material of the final separating column with a mineral acid of different concentrations of 0.1-2.5 M, and (f) eluting the lutetium-177 ions from the final separating column by a highly concentrated mineral acid of 3-12 M, collecting the ultra-pure lutetium-177 eluate in an evaporation system, and removing the mineral acid by evaporation; or steps (a)-(d), (e1) continuously transporting the acidic lutetium-177 eluate from step the (d) to the input of a third column (VS2), which is packed with the cation exchange material, where the cation exchange material is present in protonated form by the loading with the acidic lutetium-177 eluate, replacing the protons of the cation exchange material for ammonium ions using a solution of ammonium chloride, and rinsing the cation exchange material of the third column with water, (f1) connecting the output of the third column with the input of a fourth column (S2), which is packed with cation exchange material, (g) applying a gradient of water and complexing agent including HIBA, citric acid, citrate, butyric acid, butyrate, EDTA, EGTA, and ammonium ions, starting from 100% of water-0.2 M complexing agent to the input of the third column, (h) detecting the radioactivity dose at the output of the fourth column, to detect elution of lutetium-177 compounds, collecting a second eluate of lutetium-177 compounds from output of the third column in a container, and protonating the complexing agent to make them ineffective for the complex formation with lutetium-177 ions, (i) loading a fifth column, which is packed with cation exchange material, by continuous propagation of the acidic lutetium-177 eluate obtained from the step (h) to the input of the fifth column, washing the complexing agent with dilute mineral acid at a concentration of less than 0.1 M, removing foreign metal ion traces from the lutetium-177 solution by washing the cation exchange material of the fifth column with mineral acid of different concentrations of 0.1-2.5 M, and (j) eluting the lutetium-177 ions from the fifth column by a concentrated mineral acid of 1-12 M, collecting the ultra-pure lutetium-177 eluate in the evaporation system, and removing the mineral acid by evaporation. An independent claim is also included for carrier-free lutetium-177 compound produced by the above mentioned method.
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