DETECTION OF A TARGET ANTIGEN IRRESPECTIVE OF THE PRESENCE OR ABSENCE OF A CORRESPONDING THERAPEUTIC ANTIBODY

摘要

DETECTION OF A TARGET ANTIGEN IRRESPECTIVE OF THE PRESENCE OR ABS OF A CORRESPONDING THERAPEUTIC ANTIBODY ABSTRACT THE PRESENT INVENTION RELATES TO THE FIELD OF THERAPEUTIC ANTIBODIES. THE INVENTION ESPECIALLY RELATES TO A METHOD OF DETECTING THE TAR-ET ANTIGEN OF A THERAPEUTIC ANTIBODY IN A SAMPLE COMPRISING THE STEPS OF A) PROVIDING THE SAMPLE TO BE 5 ANALYZED, B) INCUBATING SAID SAMPLE WITH SAID THERAPEUTIC ANTIBODY UNDER CONDITIONS APPROPRIATE FOR BINDING OF SAID THERAPEUTIC ANTIBODY TO SAID TARPET ANTI EN, WHEREBY A TARGET ANTIGEN-THERAPEUTIC ANTIBODY-COMPLEX IS FORMED, AND C) 9 I 0 DETECTING THE COMPLEX FORMED IN (B). C, O I