Copper (II) -Mixed Ligand Complexes with Anticancer Properties

摘要

THE PRESENT INVENTION DISCLOSES PHARMACEUTICAL COMPOSITION HAVING AT LEAST ONE OF THE SERIES OF TERNARY COPPER(II) COMPLEXES, [CU(PHEN)(AA)(H2O)]NO3•xH2O FROM 1,10-PHENANTHROLINE AND AMINO ACID LIGANDS. THE SAID AMINO ACID LIGANDS ARE GLYCINE (GLY), SARCOSINE (SAR), DL-ALANINE (DL-aLa), OR 2,2-DIMETHYLGLYCINE (C-dMg). THE SERIES OF TERNARY COPPER(II) COMPLEXES WITH ANTICANCER PROPERTIES ARE FURTHER CHARACTERIZED BY SELECTIVELY TOWARDS CANCER CELLS. THE ANTICANCER PROPERTIES ARE DUE TO INCREASE REACTIVE OXYGEN SPECIES (ROS) GENERATION, SELECTIVE INDUCTION OF NUCLEAR DOUBLE STRAND DNA BREAKS (DSBs), CELL CYCLE ARRESTED AT GO/G1, PROTEASOME INHIBITION, OXIDATIVE DNA DAMAGE AND TOPOISOMERASE I (TOPO I) INHIBITION. MOST ILLUSTRATIVE DIAGRAM: FIGURE 1