New substituted quinoline compounds as inhibitors of S-nitrosoglutathione reductase

摘要

The compound of Formula I: ** Formula ** wherein m is selected from the group consisting of 0, 1, 2 or 3; R1 is independently selected from the group consisting of chlorine, fluorine, bromine, cyano and methoxy; R2b and R2c are independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy and N (CH3) 2; X is selected from the group consisting of n is selected from the group consisting of 0, 1 and 2; R3 is independently selected from the group consisting of halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy and NR4R4 'where R4 and R4' are independently selected from the group consisting of C1-C3 alkyl , or R4 when taken together with R4 'forms a ring with 3 to 6 members; and A is selected from the group consisting of or a pharmaceutically acceptable salt, stereoisomer or N-oxide thereof.