Protein peptide conjugates associated with the fucosidase inhibitor receptor and its use in the treatment of liver tumors

摘要

A peptide conjugate comprising a receptor-associated protein (RAP) peptide bound to a fucosidase inhibitor, the RAP peptide comprising a polypeptide sequence with at least 80% homology to amino acids 210-319 of RAP of the SEQ ID NO: 1, wherein the fucosidase inhibitor inhibits the activity of alpha-L-fucosidase to cleave fucose residues from glycoproteins and induces the accumulation of glycoprotein-derived oligosaccharides in the lysosome, where the fucosidase inhibitor is selected from the group consisting of L-deoxifuconojirimycin (DFJ), beta-1- C-methyl-deoxyimanojirimycin, beta-1-C-ethyl-deoxyimanojirimycin, beta-1-C-phenyl-deoxyimanojirimycin, acid ((3R, 4R, 5S , 6S) -1-butyl-4,5,6-trihydroxyazepane-3-carboxylic acid (Faz), beta-L-homofucononojirimycin, (1-alpha, 2-beta, 3- alpha or beta, 4-alpha, 5- alpha or beta) -2,3,4-trihydroxy-5- (hydroxymethyl) -cyclopentylamines substituted and 2,6-imino-2,6,7-trideoxy-D-glycerol-D-gluco-heptite l.