Synthesis of disodium salt of N4- (2,2-dimethyl-4 - (dihydrogen phosphonoxy) methyl -3-oxo-5-pyrido 1,4 oxazin-6-yl) -5-fluoro-N2- ( 3,4,5-trimethoxyphenyl) -2,4-pyrimidinediamine

摘要

A process for preparing a compound of formula I: ** Formula ** comprising: a) contacting an acid solvate of a compound of formula II: ** Formula ** with an amide under appropriate conditions to form a solvate of amide of the compound of formula II; and b) contacting the amide solvate with an aqueous base comprising sodium ions under appropriate conditions to form the compound of formula I.