Transdermal therapeutic system with small tendency to spontaneous crystallization

摘要

Transdermal therapeutic system (TTS) comprising a back layer impermeable to the active substance, a matrix consisting of one, two or more layers and a removable protection layer, characterized in that the matrix layer or layers or at least one of the layers The matrix comprises at least one self-adhesive glue, at least one medicament and transversely cross-linked polyvinylpyrrolidone particles, and during the manufacture of the matrix layer or layers containing medicament and / or the coating of the back layer impermeable to the active substance of the system A transdermal therapeutic treatment has been carried out at a temperature at which the temperature was above the melting point or the melting point range of the stable modification of the drug or medicaments, preferably at least 10 ° C above the melting point or the range of melting said stable modification, the self-adhesive glue consisting of a glue a Fuse sticker.