Method for determining optimized parameters of a device that generates a plurality of ultrasound beams focused in a region of interest

摘要

An in vitro method for determining optimized parameters of a device (1) generating a plurality of ultrasound beams that are focused on a focal point P located in a region of interest (V) which may be a region within means (4) or a region (S) interface between a first and a second fluid medium (4), so that said device (1) occurs around the focal point P within the region of interest ( V) at least one selected from effect: - a cavitation effect located within the region of interest (V) located inside the means (4), - an effect of simple acoustic source located in the region of interest ( V) which it is at the interface (S) between a first and a second fluid medium (4), - an effect of temperature increase located within the region of interest (V) inside the means (4), wherein said method comprises the following steps: a) providing a disposi tive (1) comprising: - at least two signal generators (21, 22) respectively generate a first signal s1 having an amplitude A1 and a second signal s2 having an a2 amplitude, - at least two means of ultrasound ( 11, 12) being adapted such at least means of ultrasound (11, 12) respectively: - to receive the first signal s1 so as to generate a first beam B1 from a first ultrasonic wave inside the means (4) to a first beam direction D1, being focused said first beam B1 on a first acoustic focal point P1a within said region of interest (V), - to receive the second signal s2 so as to generate a second beam B2 of a second ultrasonic wave into the medium (4) to a second beam direction D2, being focused said second beam B2 on a second acoustic focal point P2a inside the region of interest (V), - at least one means of detecting (16) the at least one ef ecto, b) positioning the at least two means of ultrasound (11, 12) together so that the first and second directions D1, D2 are approximately coplanar and inclined relative to each other in a understood α angle between 60 ° and 120 °, c) moving at least two means of ultrasound (11, 12) respectively in at least two displacements x1, x2 so as to detect at least one effect within the region of interest (V) around the focal point P on which overlap the first and second focal points acoustic P1a and P2a and not detected outside the region of interest (V), characterized by further comprising the steps of: d) reducing the amplitude a1, a2 signals s1 , s2 up to an amplitude level in which the at least one effect is not detected, e) moving the at least two means of ultrasound (11, 12) to a plurality of test positions, each corresponding one of said test positions to said position means ultr asonidos to which at least one means of ultrasound (11, 12) has moved through increased displacement D, f) if the at least one effect is detected in one of the test positions in step e) around the focal point P on the first and second acoustic focal points P1a and P2a overlap, selecting said test position to the position of the ultrasonic means, and repeating steps d) and e), g) determine and record optimized device parameters (1) are the amplitudes a1, a2 of s1, s2 and signals x1, x2 ultrasonic means (11, 12) adjusted position before the last reduction in step d).