POLYPEPTIDES INVOLVED IN SPIRAMYCIN BIOSYNTHESIS, NUCLEOTIDE SEQUENCES ENCODING SAID POLYPEPTIDES AND USES THEREOF

摘要

the present invention relates to the isolation and identification of newthe genes of the biosynthetic pathway of spiramycines and new polypeptidesinvolved in this biosynthesis. the invention is also related to aprocess for the production of such polypeptides. it is also related tothe use of these genes in order to increase the rate of production.the purity of spiramycin production. the invention relates in particular to amicroorganism producing spiramycin i but do not producespiramycin ii and iii and the use of such a micoorganisme. the invention hasalso related to the use of genes of the biosynthetic pathway offor the construction of spiramycines mutants that can lead to the synthesis ofnew antibiotics and derivatives of spiramycines. the inventionfor the molecules produced by the expression of these genes.pharmacologically active compositions of a molecule produced bythe expression of such genes _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _