SALIVARY MRNA PROFILING, BIOMARKERS, AND RELATED METHODS AND KITS OF PARTS

摘要

A method to detect a biomarker in saliva wherein the biomarker is anextracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting atranscriptome pattern in the cell-free saliva; a method to detect geneticalterations in an organ or in a gene in the organ by analyzing saliva,comprises detecting a transcriptome pattern and/or the mRNA profiling of thegene in cell-free saliva; a method to diagnose an oral or systemic pathologydisease or disorder in a subject, comprises: detecting profile of a biomarkerassociated with the pathology disease or disorder, in particular mRNA and/orprotein, in cell-free saliva and/or serum; kits comprising identifier for atleast one biomarker for performing at least one of the methods; and use ofsalivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/orsystemic pathology, disease or disorder.