COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF ANTI-APOPTOTIC GENES

摘要

The present invention relates to a double-stranded ribonucleic acid (dsRNA)for inhibiting the expression of an anti-apoptotic gene, comprising anantisense strand having a nucleotide sequence which is less that 25nucleotides in length and which is substantially complementary to at least apart of an apoptotic gene, such as a Bcl gene. The invention also relates to apharmaceutical composition comprising the dsRNA together with apharmaceutically acceptable carrier; methods for treating diseases caused bythe expression of an anti-apoptotic gene using the pharmaceutical composition;and methods for inhibiting the expression of an anti-apoptotic gene in a cell.