METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION USING ISOTHIAZOLOPYRIMIDINONES

摘要

The present invention provides methods and compositions comprising compoundsuseful for stimulatingneurogenesis. The methods and compositions comprising compounds are alsouseful for inhibiting neuronal degeneration. Thus, the presentinvention can be used in the treatment of diseases and conditionscharacterized by neuronal loss and reduced neurogenesis includingAlzheimer's disease, stroke, traumatic brain injury, traumatic nerve injury,and depression. This invention is useful for researchproducts including single agents or mixtures of agents to promote,proliferate, differentiate, or maintain neurons from stem orprogenitor cells.