MYCOPLASMA HYOPNEUMONIAE AVIRULENT ADJUVANTED LIVE VACCINE

摘要

Provided are immunogenic and vaccine compositions and methods for theirpreparation and use, whichcompositions are effective in protecting against, minimizing the severity of,preventing, and/or ameliorating M. hyopneumoniae infection.Administration to an animal of one or two doses of an adjuvanted liveavirulent M. hyopneumoniae composition disclosed hereinis effective in providing immunity to the animal and protection from infectionwith a virulent strain of M. hyopneumoniae therebyreducing the severity of and/or preventing disease caused by one or morevirulent strain of M. hyopneumoniae. Also provided arecompositions, which further comprise one or more antigen such as, for example,one or more live bacteria, bacterin, toxoid, and/orvirus and/or viral antigen. Exemplified are immunogenic compositions,comprising an adjuvanted live avirulent M. hyopneumoniaeand compositions, comprising Porcine Circovirus Type 1-Type 2 chimera modifiedlive vaccine (cPCV1-2) in further combinationwith an adjuvanted live avirulent M. hyopneumoniae.