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LACTATE-BASED POLYMER CONTROLLED RELEASE DRUG DELIVERY COMPOSITIONS WITH IMPROVED STABILITY
LACTATE-BASED POLYMER CONTROLLED RELEASE DRUG DELIVERY COMPOSITIONS WITH IMPROVED STABILITY
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机译:乳酸基聚合物控制的释放药物释放组合物,具有提高的稳定性
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摘要
The present invention provides an injectable composition for controlled release drug delivery and the process of making the same, where the composition comprises: a lactate-based polymer having a weight average molecular weight between 5,000 and 50,000 dalton, an acid number of less than 3 mgKOH/g and the content of residual lactide monomers in the lactate-based polymer of less than about 0.3% by weight; a pharmaceutically acceptable organic solvent; and a bioactive substance or a salt thereof that contains an amino acid serine in the molecular structure that is capable of reacting with lactide monomer to form a conjugate; and where the composition reduces the formation of the conjugate.
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