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COMBINATION THERAPY TO TREAT CANCER COMPRISING DENDRITIC CELLS ENGINEERED TO OVEREXPRESS P53 AND AN IMMUNE CHECKPOINT INHIBITOR
COMBINATION THERAPY TO TREAT CANCER COMPRISING DENDRITIC CELLS ENGINEERED TO OVEREXPRESS P53 AND AN IMMUNE CHECKPOINT INHIBITOR
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机译:联合治疗包含过度表达P53的树突状细胞和免疫检查点抑制剂的治疗
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摘要
A method is disclosed for treating small cell lung cancer (SCLC) in a subject that involves administering to the subject a therapeutically effective amount of dendritic cells engineered to overexpress p53. In some embodiments, the method further involves administering to the subject a therapeutically effective amount of all-trans-retinoic acid (ATRA). The method can also involve administering to the subject a therapeutically effective amount of an immune checkpoint inhibitor.
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