SCREEN OF SCHISTOSOMA MANSONI DIAGNOSTIC ANTIGEN AND USE

摘要

Disclosed are screen of Schistosoma mansoni diagnostic antigens and a use thereof. In particular, the antigens are from Schistosoma mansoni, and the antigen combination comprises two or more antigens selected from the group of: (a) polypeptides shown as SEQ ID NOs:1-17; (b) derived polypeptides having immunogenicity formed by one or more amino acid residue(s) substitutions, deletions or additions from the amino acid sequences of SEQ ID NOs:1-17; (c) polypeptides having immunogenicity, with ≥90% homology with the amino acid sequences shown as SEQ ID NOs:1-17; or (d) the fragment of polypeptides (a) - (c) having immunogenicity, wherein antigens in the antigen combination are directed at different antibodies. The Schistosomiasis mansoni serologic detection indicates that using these positive antigens for detecting Schistosoma mansoni have a high sensitivity and specificity. Also provided in the present invention are a method and a kit for correspondingly diagnosing and monitoring the Schistosomiasis mansoni disease.