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COMBINATION THERAPY TO ENHANCE THE ANTICANCER EFFICACY OF PLATINUM DRUGS

机译：组合疗法可增强白药的抗癌作用

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摘要

The present invention relates to compositions and methods for reducing cell proliferation and/or promoting cell death. It is based, at least in part, on the discovery that in platinum drug-resistant cell lines, certain compounds, together with a second antiproliferative agent (e.g., cisplatin), act synergistically to promote apoptosis. Accordingly, the present invention provides for novel anticancer strategies.

机译：本发明涉及用于减少细胞增殖和/或促进细胞死亡的组合物和方法。这至少部分基于以下发现：在铂耐药细胞系中，某些化合物与第二种抗增殖剂（ g 。，顺铂）共同起到促进细胞凋亡的作用。因此，本发明提供了新颖的抗癌策略。 展开▼

著录项

公开/公告号WO2015195951A1

专利类型

公开/公告日2015-12-23

原文格式PDF

申请/专利权人 UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;
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申请/专利号WO2015US36485

发明设计人 QIAN WEI;WIPF PETER;VAN HOUTEN BENNETT;
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申请日2015-06-18

分类号A61K31/517;A61K31/513;A61P35;

国家 WO

入库时间 2022-08-21 14:19:54

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