A DNA methylation and genotype specific biomarker of suicide attempt and/or suicide ideation

摘要

The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict suicide ideation and/or suicide attempt. In one embodiment, a method for predicting suicide ideation and/or attempt by a subject comprises the steps of (a) measuring the DNA methylation level of a CpG dinucleotide in the 3' untranslated region of SKA2; (b) identifying the genotype at a SNP within the 3' UTR of SKA2, and (c) predicting suicide ideation and/or attempt by the subject using a prediction algorithm.