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PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) AND PEPTIDE DERIVATIVES THEREOF FOR USE IN OSTEOBLAST DIFFERENTIATION AND BONE GROWTH
PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) AND PEPTIDE DERIVATIVES THEREOF FOR USE IN OSTEOBLAST DIFFERENTIATION AND BONE GROWTH
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机译:色素上皮衍生因子(PEDF)及其肽衍生物可用于成骨细胞的分化和骨生长
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摘要
The present invention provides compositions and methods for differentiating a stem cell into an osteoblast or osteoblast progenitor cell. In certain embodiments, the invention may be used for promoting bone formation and increasing bone mass. In one embodiment, the composition comprises an agent which increases PEDF expression, PEDF activity, or both. In one embodiment, the composition comprises full-length PEDF. In one embodiment, the composition comprises a PEDF fragment or PEDF-derived peptide.
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