CXCL14 AS A BIOMARKER OF HEDGEHOG PATHWAY ACTIVITY FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS

摘要

Disclosed are methods using CXCL14 as a systemic biomarker for prognosing, diagnosing, and/or treating a condition mediated, in whole or in part, by the Hedgehog pathway including interstitial lung disease (such as idiopathic pulmonary fibrosis), pulmonary and non-pulmonary fibrotic conditions, and cancer. Also disclosed are methods using CXCL14 as a systemic biomarker to monitor disease progression as well as the efficacy of Hedgehog and non-Hedgehog pathway therapies for treating a condition mediated, in whole or in part, by the Hedgehog pathway including interstitial lung disease (such as idiopathic pulmonary fibrosis), pulmonary and non-pulmonary fibrotic conditions, and cancer.