PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, MIXTURE EXTRACT OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF

摘要

The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of moutan root bark (Moutan Radicis Cortex), Angelica dahurica root (Angelicae Dahuricae Radix) and bupleurum root (Bupleuri Radix), or a fraction thereof. Specifically, the mixture extract of the present invention simultaneously exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the mixture extract significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the mixture extract of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.