NARROW-SPECTRUM ANTIBACTERIAL ANTIBIOTICS TARGETING SPECIFIC TYPES OF BACTERIA THAT SYNTHESIZES MENAQUINONE THROUGH AN ALTERNATIVE PATHWAY VIA FUTALOSINE OR 6-AMINODEOXYFUTALOSINE AS AN INTERMEDIATE.

摘要

Alternative menaquinone biosynthetic pathway via futalosine or 6-aminodeoxyfutalosine as an intermediate (futalosine pathway) is an attractive target for new narrow-spectrum antimicrobial agents. Siamycin I and fatty acids were provided as selective antimicrobial activity against bacteria such as Helicobacter and Campylobacter, which depend on the futalosine pathway to grow. Specifically, siamycin I and omega-3 polyunsaturated fatty acids inhibited the colonization of H. pylori in vivo and thus siamycin I and omega-3 polyunsaturated fatty acids could be a new narrow-spectrum antibiotic for Helicobacter and Campylobacter