INHIBITORS OF MIRNAS IN REGULATION OF ARTERIAL STIFFNESS AND USES THEREOF

摘要

The present invention provides methods of treating or preventing arterial stiffness in a subject by administering to the subject an inhibitor of miR-137 function or activity and/or an inhibitor of miR-138 function or activity. The present invention also provides methods of treating or preventing one or more conditions associated with arterial stiffness by inhibiting the function or activity of miR-137 and/or miR-138. The present invention further provides methods of modulating the activity or expression of miR-137 and/or miR-138 in cells of a subject.