PYRROLOTRIAZINONE AND IMIDASOTRIAZINONE DERIVATIVES AS OBIQUITIN-SPECIFIC PROTEASE 7 CUSP? ) INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER USP7 MEDIATED DISEASES

摘要

The invention relates to pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one and imidazo[5,1-f][1,2,4]triazin-4(3H)-one derivatives as inhibitors of the ubiquitin-specific protease 7 (USP7) useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula (I) where R_l, R₂, R₃, R₄, R_s, R_s', R₆, X_l, X₂, m, and n are described herein.